Whipple’s Disease with Endocarditis

Published July 5, 2025

N Engl J Med 2025;393:175

DOI: 10.1056/NEJMicm2413719

Abstract

A 51-year-old man presented with a 3-month history of weight loss, diarrhea, and fever. Transthoracic echocardiography showed vegetations on the aortic and mitral valves. A duodenal biopsy showed periodic acid–Schiff–positive macrophages.

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This article was published on July 5, 2025, at NEJM.org.

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Published online: July 5, 2025

Published in issue: July 10, 2025

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Leipzig Heart Center, Leipzig, Germany

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