There are meds like dopamine boosters or calcium channel drugs. Some opioids, muscle relaxants, and sleep meds might also do the trick.
Home remedies can help too. A warm bath, massage, or hot/cold packs can ease limb sensations. Magnesium supplements might work. Since fatigue makes RLS worse, a solid sleep routine helps.
Moderate, regular exercise can relieve symptoms, but overdoing it or working out late can backfire. Cutting caffeine might also be a good move.