Popeye Sign in Transthyretin Amyloidosis

Published August 30, 2025

N Engl J Med 2025;393:906

DOI: 10.1056/NEJMicm2503880

Abstract

A 75-year-old man presented with a 3-week history of fatigue and palpitations. Bulging of the biceps during elbow flexion was noted. ECG showed low-voltage QRS complexes, and echocardiography showed left ventricular hypertrophy.

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This article was published on August 30, 2025, at NEJM.org.

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Published online: August 30, 2025

Published in issue: September 4, 2025

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